Saturday, April 28
Genetic Engineering of Hematopoiesis to Treat Inherited Diseases
Serena Scala, San Raffaele Telethon Institute for Gene Therapy, Italy
Serena Scala is Post-Doc in the group of Prof. Alessandro Aiuti at San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) in Milan. She is PhD in Molecular Medicine. Her main interests are hematopoiesis, gene therapy and integration site-clonal tracking. Her works combine deep multi-parametric phenotyping and integration site analyses aimed at studying the biology of the hematopoietic system and at evaluating dynamics of hematopoietic reconstitution upon gene therapy. She is currently investigating the role of distinct hematopoietic/stem and progenitor subpopulations during early reconstitution after transplantation and at steady state. She recently developed with her collaborators a novel flow-cytometry technology, currently under patent filing, with a wide range of pre-clinical and clinical applications going from the characterization of hematopoietic disorders to the monitoring of hematopoietic reconstitution and stem cell maintenance in patients after transplant or gene therapy.
Sunday, April 29
1700 -- 1800
Robert Hooke Lecture
Luminescent dots for multiplexing cytometry and super-resolution imaging
Dayong Jin, University of Technology Sydney, Australia
Distinguished Professor Dayong Jin is a former ISAC scholar (awarded in 2007). He directs the Australian Research Council IDEAL Research Hub and Institute for Biomedical Materials & Devices (IBMD), at the University of Technology Sydney. His research has been in the physical, engineering and interdisciplinary sciences. He is a technology developer with expertise covering optics, luminescent materials, sensing, automation devices, microscopy imaging, and analytical chemistry to enable rapid detection of cells and molecules and engineering of sensors and photonics devices. Prof Jin is the winner of the Australian Museum Eureka Prize for Interdisciplinary Scientific Research in 2015, the Australian Academy of Science John Booker Medalist in 2017, and the Prime Minister’s Malcolm McIntosh Prize for Physical Scientist of the Year 2017.
Tuesday, May 1
1345 – 1445
Roger Tsien Keynote Lecture
Roger Tsien's Heritage: Investigating Live Cells in Action
Tullio Pozzan, National Research Council of Italy
Tullio Pozzan graduated in Medicine in 1973 at the University of Padova, from 1978 to 1981 worked as post doc at the Department of Biochemistry in Cambridge (UK) and was nominated full Professor of General Pathology at the University of Ferrara in 1986. In 1990 he returned to the University of Padova where he served as Department Chairman for 12 years. At present Prof. Pozzan is head of the Department of Biomedical Sciences of the National Research Council (CNR).
His main scientific interest over the last 30 years has been the study of Ca2+ as a universal intracellular second messenger. His interests in Ca2+ signaling began with the characterization, in isolated organelles, of the mitochondrial Ca2+ homeostatic mechanisms. During the post doc, in collaboration with R.Y. Tsien (Nobel laureate in 2008), he participated to the development of the intracellular trappable fluorescent Ca2+ indicators and using these tools he clarified a number of key questions in cell activation. His research group developed the first genetically encoded probes with selective subcellular localization (targeted aequorins). This new approach lead to a series of novel discoveries on the mechanisms of subcellular Ca2+ handling and in particular to the understanding of how mitochondria participate in cellular Ca2+ handling. His present interests focus on a detailed description of the mechanisms of Ca2+ uptake and release in mitochondria in vivo, on the role of Ca2+ signaling in neuron-glia cross talk and on the role of altered mitochondrial Ca2+ handling in neurodegenerative diseases. Finally over the last years he became interested also in the signaling pathway controlled by the other universal intracellular messenger, cAMP. His group generated the first genetically encoded fluorescent cAMP probe and contributed to establishing the concept of cAMP microdomains. Recently he described the existence and regulation of an autonomous cAMP generation and hydrolysis mechanism within the matrix of mitochondria.